Tuning and performance is really a black magic art as it involves so many different interlocked factors.
In your scenario however you should be most concerned about I/O bandwidth. I'm assuming most clients will be using IMAP to get their mail. If the disk subsystem can't keep up with the traffic generated, clients are going to see slow response times.
If you start seeing this there a some remedies which may help.
- Have several store partitions spread across several seperate physical disks (spindles) and spread the users among these partitions
- Upgrade your I/O controller. If you find yourself outrunning a Ultra160 SCSI controller, get another one and put some disks on it and create some store partitions there.
- Make sure the message queue and the store are not on the same physical disk. Same goes for the logs, all these actions are I/O intensive, try to keep them seperate.
Hope this helps a bit.
-Chris